This course includes fundamental EHS risk assessment concepts and internationally accepted risk assessment terminology. The authors will discuss exposure assessment priorities and health risk ratings. A Modified Health Risk Rating (HRR) and IH Failure Mode and Effect Analysis methodology were developed for this course. Nanomaterials risk assessment tool will be discussed briefly since one of the case studies includes nanomaterials. Most of the risk assessment tools are linear. Therefore, a new IH risk assessment tool was developed to address the additive or synergistic effects of multiple chemicals exposures. A dermal exposure risk assessment tool is also included in the course materials.